K.KULAZHANOV KAZAKH UNIVERSITY OF TECHNOLOGY AND BUSINESS
Ensure healthy lives and promote well-being for all at all ages Suleimen Yerlan Melsuly - AP19679527 "Isolation, establishment of the structure and antitumor activity of antibiotics from lichen fungi of the Akmola region". The project is aimed at finding and studying new natural biologically active compounds with antimicrobial and antitumor properties, with the prospect of their use in medicine and pharmaceuticals. The relevance of the project is due to the growing resistance of microorganisms to existing antibiotics, as well as the need to develop new antitumor drugs of natural origin. Endolichen fungi living inside lichens are a poorly studied, but promising source of unique metabolites with high biological activity. The aim of the study is to isolate new antibiotic compounds from endolichen fungi, establish their chemical structure and study their physicochemical properties, as well as assess their antitumor and antimicrobial activity. The main idea of the project is the systematic study of lichen fungi of the Akmola region in order to obtain biologically active extracts. As part of the work, active substances with a wide range of activity will be isolated and purified, including the effect on pathogenic microorganisms, such as the fungus Cryptococcus neoformans, which causes severe infections, including complications of viral diseases. Particular attention will be paid to establishing the chemical structure of the isolated compounds using modern methods of spectroscopy and chromatography. This will allow not only to identify new natural antibiotics, but also to identify patterns of their biological activity. The project also plans to conduct comprehensive biological studies aimed at assessing the antimicrobial, antitumor, antioxidant and cytotoxic activity of the isolated compounds. The data obtained will make it possible to identify promising substances for further preclinical studies. The practical significance of the project lies in the formation of a scientific basis for the development of new medicines based on natural compounds, as well as in expanding knowledge about the biodiversity and biotechnological potential of endolichen fungi in the region. The expected result of the project will be the production of a number of biologically active extracts and the isolation of new antibiotics with proven antitumor activity, which can contribute to the development of domestic pharmaceuticals and the creation of innovative drugs for the treatment of infectious and oncological diseases. Mukhtar Chumanovich Tultabaev - AR23488817 "Development of technologies for the production of fortified drinks enriched with oxygen using the Scheffe simplex-lattice plan". The project is aimed at creating a scientifically sound and technologically efficient platform for the production of functional drinks of a new generation. The main goal of the project is to develop a technology for producing fortified water-based drinks saturated with oxygen, capable of providing the human body with the necessary micro- and macronutrients, as well as helping to improve immunity, performance and overall health. The relevance of the project is due to the growing demand for functional nutrition products aimed at preventing diseases and maintaining an active lifestyle. In this regard, the development of beverages that combine the properties of a carrier of biologically active substances and an additional source of dissolved oxygen is of particular importance. The scientific novelty of the study lies in the theoretical substantiation and experimental confirmation of the possibility of using oxygen-containing fortified drinks to increase the efficiency of assimilation of nutrients and strengthen the immune system. For the first time, a mathematical model for optimizing beverage formulations based on the Scheffe simplex-lattice plan will be developed, which makes it possible to determine the optimal ratios of components, taking into account their synergistic interaction and influence on the organoleptic and functional properties of the product. The key focus of the project is to solve the problem of low solubility of oxygen in water under normal conditions. For this purpose, it is planned to introduce innovative methods of oxygen saturation of the liquid, ensuring an increase in the concentration of dissolved gas and its stable retention without the use of hyperbaric conditions. The use of microbubble technology will increase the efficiency of the transfer of vitamins, minerals and other biologically active substances in the process of their assimilation by the body. The project also includes the development and creation of an experimental production line for the production of new types of beverages. The technological process will include the stages of water treatment, vitamin and mineral enrichment, oxygen saturation, as well as product quality and stability control. Special attention will be paid to the development of regulatory and technical documentation to ensure product compliance with safety, quality and consumer characteristics requirements. The practical significance of the project lies in the possibility of expanding the range of functional beverages, developing small and medium-sized businesses, as well as reducing dependence on imported products. The use of local raw materials and the introduction of innovative technologies will increase the economic efficiency of processing enterprises and increase their profitability by 20-30%. As a result of the project, a scientifically and technologically sound system for the production of fortified beverages will be created, contributing to improving the quality of life of the population and the formation of a healthy food culture. Omaralieva Aigul Makhmutovna - AP09561622 "Development of technology for the production of gluten-free flour confectionery products using flour from leguminous seeds grown in Kazakhstan". The project is aimed at creating an innovative technology for the production of functional food products aimed at consumers with special dietary needs. The relevance of the project is due to the growing number of people suffering from Celiac disease, as well as the increasing demand for gluten-free products. Currently, the Kazakh market is heavily dependent on imported gluten-free products, which are characterized by high cost and limited assortment. This creates the need to develop domestic technologies that make it possible to produce affordable and high-quality products. The main idea of the project is to use local raw materials — flour from leguminous crops (peas, chickpeas, lentils, etc.), which do not contain gluten, for the production of flour confectionery products such as biscuits, muffins and other products. This will not only provide consumers with safe products, but also increase their nutritional value due to the high content of protein, dietary fiber, vitamins and minerals. The aim of the project is to develop the theoretical and practical foundations for creating gluten-free confectionery products using Kazakhstani leguminous raw materials, as well as to expand the range of functional food products. The project will investigate the properties of various types of gluten-free flour, develop optimal formulations and technological modes of production, and study the organoleptic, physico-chemical, and nutritional characteristics of the finished products. Special attention will be paid to improving the texture, taste and appearance of products, which is one of the key tasks in the development of gluten-free products. The practical significance of the project is to create affordable domestic gluten-free products, reduce dependence on imports, and develop Kazakhstan's processing industry. The use of local raw materials will reduce the cost of production and increase its competitiveness. The social effect of the project is expressed in improving the quality of life of people in need of specialized nutrition, as well as in the formation of a healthy eating culture among the population. The implementation of the project will ensure the creation of an innovative technology for the production of gluten-free flour confectionery products, expand the range of food products and strengthen the country's food security through the effective use of domestic resources.
| Correction: Squalene recovery from Uzen oil field wastewater: a novel abiotic resource (Frontiers in Environmental Chemistry, (2025), 6, (1672872), 10.3389/fenvc.2025.1672872) | Suleimen, Y.M.,Mamytbekova, | Frontiers in Environmental Chemistry, 6, 1717331 | 2025 | https://www.frontiersin.org/journals/environmental-chemistry/articles/10.3389/fenvc.2025.1717331/full |
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| Application of biodegradable packaging materials based on natural polysaccharides for food products | Botbayeva, Z. | Caspian Journal of Environmental Sciences, 23(1), страницы 249–257 | 2025 | https://www.scopus.com/pages/publications/86000648721?origin=resultslist |
| Isolation and In Silico Inhibitory Potential against SARS-CoV-2 RNA Polymerase of the Rare Kaempferol 3-O-(6″-O-acetyl)-Glucoside from Calligonum tetrapterum | Suleimen, Y.M.,Jose, R.A.,Mamytbekova, G.K.,... Eissa, I.H.,Metwaly, A.M. | Plants, 11(15), 2072 | 2022 | https://www.scopus.com/pages/publications/85136919354?origin=resultslist |
| Constituent Composition and Biological Activity of Essential Oil from Artemisia sublessingiana | Suleimen, E.M.,Ibataev, Z.A.,Suleimen, R.N.,Mamytbekova, G.K. | Chemistry of Natural Compounds, 58(4), pp. 766–769 | 2022 | https://link.springer.com/article/10.1007/s10600-022-03790-y |
| Detection of chest pathologies using autocorrelation functions | Abdikerimova, G.,Shekerbek, A.,Tulenbayev, M.,... Manbetova, Z.,Baibulova, M. | International Journal of Electrical and Computer Engineering, 13(4), pp. 4526–4534 | 2023 | https://ijece.iaescore.com/index.php/IJECE/article/view/30842 |
| Establishing the regularity of the emulsification process | Bekturganova, A.,Mukanova, K.,Zhumanova, U.,Tultabayev, B. | Bio Web of Conferences, 64, 01012 | 2023 | https://www.bio-conferences.org/articles/bioconf/abs/2023/09/bioconf_abt2023_01012/bioconf_abt2023_01012.html |
| Development of functional food products based on safflower oil | Bekturganova, A.,Mukanova, K.,Zhumanova, U.,Tultabayev, B. | Bio Web of Conferences, 64, 01008 | 2023 | https://www.scopus.com/pages/publications/85195642026?origin=resultslist |
| Optimization of the protein product formulation based on safflower production waste | Tultabayev, M.,Zhumanova, D. | Bio Web of Conferences, 64, 01018 | 2023 | https://www.bio-conferences.org/articles/bioconf/abs/2023/09/bioconf_abt2023_01018/bioconf_abt2023_01018.html |
| Denaturation of proteins under the influence of ultrasound. Hypothesis | Tultabayev, M.,Zhumanova, D. | Bio Web of Conferences, 64, 01007 | 2023 | https://www.bio-conferences.org/articles/bioconf/abs/2023/09/bioconf_abt2023_01007/bioconf_abt2023_01007.html |
| Component composition of essential oil of Rhodiola algida (Ledeb.) Fisch & C.A. Mey and its biological activity | Zhumagul, M.Zh.,Kubentayev, S.A.,Kurmanbayeva, M.S.,... Suleimen, Y.M.,Samarkhanova, D. | International Journal of Biology and Chemistry, 16(1), pp. 113–127 | 2023 | https://www.scopus.com/pages/publications/85208626883?origin=resultslist |
| Computational module of the cardiac electrophysiology system for analysing risk factors in cardiovascular disease | Tolagay Kabdeshov; Serik Kulmamirov | 2024 IEEE Aitu Digital Generation Conference Proceedings Aitu | 2024 | https://ieeexplore.ieee.org/document/10585579 |
| Detection of heart pathology using deep learning methods | Aigul Shaikhanova | International Journal of Electrical and Computer Engineering, 2023 | 2023 | https://ijece.iaescore.com/index.php/IJECE/article/view/32645/16992 |
| Heavy Metals Analysis, Gcms-Qp Quantification Of Flavonoids, Amino Acids And Saponins, Analysis Of Tannins And Organoleptic Properties Of Powder And Tincture Of Echinacea Purpurea (L.) And RhapÓNticum CarthamoÍDes | Samat Amanzholov | Potravinarstvo Slovak Journal of Food Sciences, 2021 | 2021 | https://potravinarstvo.com/journal1/index.php/potravinarstvo/article/view/1476 |
| Isolation and in Silico Anti-COVID-19 Main Protease (Mpro) Activities of Flavonoids and a Sesquiterpene Lactone from Artemisia sublessingiana | Roza I. Jalmakhanbetova, Yerlan M. Suleimen | Journal of Chemistry, 2021 | 2021 | https://onlinelibrary.wiley.com/doi/10.1155/2021/5547013 |
| Influence of meteorological conditions on the level of pollution of the airale territories | Ainagul, Kolpek; Yesselkhanova G.A. | Systematic Reviews in Pharmacy, 2020 | 2020 | https://www.scopus.com/pages/publications/85105897879?origin=organizationpage |
| Effect of Phytoadditive and ferments on the physical, chemical and Organoleptic properties of fermented milk product | Amanzholov, Samat | International Journal of Pharmaceutical Research, 2020 | 2020 | http://www.ijpronline.com/ViewArticleDetail.aspx?ID=15106 |
| Accumulated substancies and calorific capacity in adipose tissue: Physical and chemical clinical trial | Pernekul Issa | Bba Clinical, 2017 | 2017 | https://www.sciencedirect.com/science/article/pii/S2214647417300089?pes=vor&utm_source=scopus&getft_integrator=scopus |