K.KULAZHANOV KAZAKH UNIVERSITY OF TECHNOLOGY AND BUSINESS
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation Suleimen Yerlan Melsuly - BR24992761 "Search for new sources of domestic competitive and safe phytopreparations for medical and veterinary use, study of their chemical properties and biological activity". The project is aimed at creating a scientific and technological base for the development of innovative medicines of natural origin based on plant raw materials of Kazakhstan. The relevance of the program is due to the need to expand the range of effective and safe medicines, as well as to reduce dependence on imported pharmaceutical products. The use of the rich biodiversity of the flora of Kazakhstan opens up broad prospects for the identification of new pharmacologically active compounds and the creation of original medicinal substances that are in demand both in medical and veterinary practice. The purpose of the program is to develop effective technologies for processing medicinal plant raw materials with the subsequent organization of the production of new biologically active substances and medicines based on them. The scientific novelty of the project lies in the comprehensive study of previously unexplored plant species growing in Kazakhstan. Extracts will be obtained from the collected plant material, from which individual compounds will be isolated using modern chromatographic methods. Particular attention will be paid to such classes of substances as terpenes, flavonoids and alkaloids, for which derived compounds will be synthesized in order to enhance or modify their biological activity. Their structure will be established using modern spectral analysis methods. For the first time, the project will conduct a comprehensive study of the antiparasitic activity of plant substances, including helminthicidal and helminthostatic effects on endoparasites both in vitro and in vivo on models of laboratory animals (rats, rabbits). Methods for assessing the viability and mobility of parasites will be developed, as well as indicators of the effectiveness of the drugs will be determined. In addition, it is planned to study the cytoprotective properties of plant extracts of the genera Achillea, Polygonum and Hedysarum, as well as to study the neurotropic effect of the active ingredients. These studies will be conducted in acute and chronic experiments in laboratory animals with the assessment of behavioral, autonomic and neurophysiological responses, including changes in motor activity, pain threshold and orientation behavior. An important stage of the project will be preclinical studies aimed at assessing the safety and efficacy of the developed substances. Indicators of acute and chronic toxicity, antioxidant, analgesic and anti-inflammatory activity, as well as mechanisms of antiparasitic and neurotropic action at the molecular and cellular level will be studied. The practical significance of the project lies in the creation of new domestic phytopreparations with proven efficacy and safety, optimization of their chemical composition and dosages, as well as the development of rational dosage forms. The implementation of the program will introduce the results of research into production, increase the competitiveness of the pharmaceutical industry of Kazakhstan and provide the population with affordable and high-quality medicines of natural origin. Mukhtar Chumanovich Tultabaev - AR23488817 "Development of technologies for the production of fortified drinks enriched with oxygen using the Scheffe simplex-lattice plan". The project is aimed at creating a scientifically sound and technologically efficient platform for the production of functional drinks of a new generation. The main goal of the project is to develop a technology for producing fortified water-based drinks saturated with oxygen, capable of providing the human body with the necessary micro- and macronutrients, as well as helping to improve immunity, performance and overall health. The relevance of the project is due to the growing demand for functional nutrition products aimed at preventing diseases and maintaining an active lifestyle. In this regard, the development of beverages that combine the properties of a carrier of biologically active substances and an additional source of dissolved oxygen is of particular importance. The scientific novelty of the study lies in the theoretical substantiation and experimental confirmation of the possibility of using oxygen-containing fortified drinks to increase the efficiency of assimilation of nutrients and strengthen the immune system. For the first time, a mathematical model for optimizing beverage formulations based on the Scheffe simplex-lattice plan will be developed, which makes it possible to determine the optimal ratios of components, taking into account their synergistic interaction and influence on the organoleptic and functional properties of the product. The key focus of the project is to solve the problem of low solubility of oxygen in water under normal conditions. For this purpose, it is planned to introduce innovative methods of oxygen saturation of the liquid, ensuring an increase in the concentration of dissolved gas and its stable retention without the use of hyperbaric conditions. The use of microbubble technology will increase the efficiency of the transfer of vitamins, minerals and other biologically active substances in the process of their assimilation by the body. The project also includes the development and creation of an experimental production line for the production of new types of beverages. The technological process will include the stages of water treatment, vitamin and mineral enrichment, oxygen saturation, as well as product quality and stability control. Special attention will be paid to the development of regulatory and technical documentation to ensure product compliance with safety, quality and consumer characteristics requirements. The practical significance of the project lies in the possibility of expanding the range of functional beverages, developing small and medium-sized businesses, as well as reducing dependence on imported products. The use of local raw materials and the introduction of innovative technologies will increase the economic efficiency of processing enterprises and increase their profitability by 20-30%. As a result of the project, a scientifically and technologically sound system for the production of fortified beverages will be created, contributing to improving the quality of life of the population and the formation of a healthy food culture. Tulegulov Amandos Dabysovich - AP23490424 "Development of an additive plant for creating metal objects for the defense industry". The project aims to create an innovative technological platform for the production of complex metal products using the selective laser melting (SLM) method. The main idea of the project is to adapt and improve existing additive technologies for working with standard metal powders, including powders with a non-spherical particle shape, which significantly expands the raw material base and reduces production costs. The project involves the development of a structural scheme for a new generation additive plant capable of manufacturing large-sized metal products with high precision and controlled physical and mechanical properties. Special attention is paid to the implementation of technical solutions aimed at increasing the stability of the printing process, improving the quality of the formed layers and reducing the likelihood of defects. A key element of the research is the creation of a mathematical model of the laser melting process of a metal powder with a non-spherical shape. The model will allow taking into account the features of heat transfer, laser energy distribution, as well as the behavior of particles in the melting zone, which will ensure more accurate adjustment of technological parameters and prediction of the quality of finished products. The project also provides for the development of parameters for a laboratory installation designed for experimental research of the selective laser melting process. The installation will be equipped with a volume shrinkage compensation system for the fused material, which will increase the geometric accuracy of the products and minimize internal stresses. Additionally, a methodology for conducting experimental studies will be developed, including the choice of printing modes, analysis of the structure and properties of the obtained samples, as well as an assessment of the effect of the shape of powder particles on the quality of products. The experimental results will become the basis for optimizing the technological process. A separate area of the project is the creation of a design for a technical system to compensate for defects caused by the non-spherical nature of metal powder. This system will help to offset negative effects such as porosity, uneven sintering and a decrease in the strength characteristics of products. The implementation of the project will make it possible to create an efficient additive plant suitable for use in the defense industry, ensuring high accuracy, reliability and cost-effectiveness in the production of complex metal components. Omaralieva Aigul Makhmutovna - BR24993031 "Development of technology for the production of confectionery products (biscuits and gingerbread) based on dry powders of melons and fruit crops". The project is aimed at creating an innovative technology for the manufacture of flour confectionery products with increased nutritional and biological value based on domestic plant raw materials. The relevance of the project is due to the growing demand for natural, functional and environmentally friendly food products, as well as the need to expand the range of confectionery products in Kazakhstan. Currently, the industry mainly uses standard ingredients and additives, while the potential of local melons and fruit crops remains insufficiently realized. The aim of the project is to scientifically substantiate and develop a technology for the production of biscuits and gingerbread, enriched with natural antioxidants, vitamins and biologically active substances through the use of dry powders from melons and fruit crops. The main idea of the project is to apply an innovative approach to the processing of plant raw materials — its drying and grinding into a powdered form while preserving useful properties. This will not only increase the nutritional value of the finished product, but also significantly increase its shelf life by reducing humidity and suppressing the development of microorganisms. The project will develop a technology for the production of confectionery products, including the selection of optimal formulations, the study of physico-chemical and organoleptic properties of products, as well as an assessment of the effect of herbal powders on the structure, taste and aroma of products. Special attention will be paid to the creation of new flavor combinations and textures that can attract consumers and increase the competitiveness of products. The use of dried melon and fruit and berry powders will provide a number of technological and economic advantages: reducing the cost of transportation and storage of raw materials, simplifying the production process, increasing the shelf life of products without the use of artificial preservatives, as well as the possibility of year-round use of seasonal raw materials. The practical significance of the project lies in the creation of a new range of healthy confectionery products focused on healthy nutrition. The implementation of the technology will increase the competitiveness of food industry enterprises, expand the sales market, including export destinations, as well as stimulate the use of local agricultural raw materials. The socio-economic effect of the project is expressed in the creation of additional jobs, the development of the processing industry and providing the population with high-quality and affordable products with improved consumer properties. As a result of the project, an efficient technology for the production of new-generation confectionery products will be developed and implemented, combining high taste qualities, long shelf life and increased nutritional value. Askar Dzhamanbaevich Shontaev - AP14971635 "Development of a progressive technology for mining hazardous coal seams based on analytical modeling of geomechanical processes in host rocks". The project is aimed at creating scientifically based and technologically effective solutions to improve the safety and efficiency of mining operations in difficult geological conditions. The urgency of the project is due to the high risk of sudden emissions of coal and gas during preparatory work, which poses a serious threat to the life and health of workers, as well as leads to significant economic losses. Existing methods of preventing such phenomena do not always provide sufficient reliability, especially in conditions of changing mining and geological factors, which requires the development of new approaches based on a deep understanding of geomechanical processes. The aim of the project is to develop a set of anti-blowout measures during mining based on the identified patterns of rock pressure and stress-strain state of the carboniferous massif using mathematical modeling methods. The main idea of the project is to create a geotechnological method for preventing sudden emissions by purposefully controlling the stress-strain state of the rock mass. This involves the impact on the most stressed areas ahead of the face and in the contiguous areas of the workings, which will reduce the likelihood of emergencies. As part of the project, an analytical and mathematical model of the geomechanical processes occurring in the host carboniferous massif will be developed. Based on the simulation, the optimal parameters for carrying out workings will be determined, taking into account specific mining, geological and engineering conditions. This will make it possible to justify effective technological solutions for managing mountain pressure and reducing the risk of emissions. The practical implementation of the project includes conducting laboratory, bench and pilot tests of the developed technologies, monitoring the condition of the array around the workings, as well as evaluating the effectiveness of the proposed solutions. Based on the research results, recommendations will be prepared for implementation in the mining industry and a feasibility study of the technology will be developed. The scientific novelty of the project is to develop new approaches to managing the geomechanical condition of the massif based on analytical modeling, as well as to create an integrated system for preventing explosive phenomena, taking into account the influence of various factors. The expected results of the project include the publication of scientific articles in highly-rated international journals, the publication of monographs, obtaining patents and copyright certificates, as well as the introduction of the developed technology in production. Additionally, the results of the study will be used in the educational process in the training of specialists in the field of Mining. The implementation of the project will significantly increase the level of industrial safety, reduce mining accidents and ensure the sustainable development of the coal industry through the introduction of innovative geotechnological solutions.
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